Hi,
Aspose.Cells for .NET is a pure .NET component (created in managed C#) is not targeted for specific .NET framework, it will work fine on any .NET framework. There is not any known issue or concern for any .NET framework including new one (i.e.., 4.0). You should use it without any issue. However, in any case, if you do find any issue on any .NET framework, we are bound to fix the issue asap.
Thank you.
Amjad Sahi
Support Developer,
Aspose Sialkot Team
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